Description

H-Ala-Arg(No2)-Ome Hcl is a chemically modified dipeptide derivative, specifically the methyl ester hydrochloride salt of alanine coupled with nitro-arginine. This compound serves as a crucial protected intermediate in advanced peptide synthesis, enabling precise control over the arginine side chain during complex molecular assembly. It is primarily utilized by research institutions and pharmaceutical development teams engaged in the creation of novel bioactive peptides, enzyme inhibitors, and other sophisticated therapeutic candidates.

Application

• Peptide Synthesis Intermediate: A key building block for the solid-phase and solution-phase synthesis of peptides containing modified arginine residues.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, where the nitro group acts as a protecting group for the guanidino function of arginine.
• Biochemical Tool Development: Employed in the design of specific enzyme substrates or inhibitors to study protease activity and signaling pathways.
• Structure-Activity Relationship (SAR) Studies: Facilitates the exploration of how modifications to the arginine side chain affect the biological activity of peptide sequences.

Basic Information

Product Name	H-Ala-Arg(No2)-Ome Hcl
CAS No.	161451-22-5
Molecular Formula	C10H21N6O5 • HCl
Molecular Weight	356.78 g/mol
Synonyms	Ala-Arg(NO2)-OMe • HCl; H-Ala-Arg(NO2)-OMe hydrochloride; Methyl N2-[(tert-butoxy)carbonyl]-N5-nitro-L-ornithyl-L-alaninate hydrochloride (related protected form); L-Alanyl-NG-nitro-L-arginine methyl ester hydrochloride; Alanine-arginine(nitro) methyl ester HCl; Peptide building block 161451-22-5; Protected dipeptide ester
EINECS	Contact for details

Quality Control

Every batch of H-Ala-Arg(No2)-Ome Hcl is subjected to rigorous analytical testing to ensure identity, purity, and consistency suitable for research and development applications. Our quality assurance protocols are designed to meet the exacting standards of the pharmaceutical and biotechnology sectors. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.