Description

Boc-Met-Nca CAS NO 161422-46-4 is a protected amino acid derivative, specifically the N-carboxyanhydride (NCA) of Boc-methionine. This compound is a critical building block in the synthesis of peptides and polypeptides via ring-opening polymerization, offering high efficiency and control over molecular weight. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing therapeutic peptides, drug delivery systems, and functional biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the controlled, stepwise synthesis of methionine-containing peptide sequences.
• Ring-Opening Polymerization (ROP): For the production of well-defined polypeptides and polyamino acids with specific chain lengths and architectures.
• Pharmaceutical Intermediate: In the research and development of novel peptide-based therapeutics, including hormones, antibiotics, and targeted drug candidates.
• Bioconjugation and Labeling: Facilitating the site-specific modification of proteins or other biomolecules due to its reactive NCA moiety.
• Biomaterials Engineering: Synthesis of biodegradable polymers and hydrogels for medical and tissue engineering applications.
• Academic and Industrial R&D: Serving as a fundamental reagent in chemical biology and synthetic chemistry research laboratories.

Basic Information

Product Name	Boc-Met-Nca
CAS No.	161422-46-4
Molecular Formula	C11H17NO6S
Molecular Weight	291.32 g/mol
Synonyms	Boc-Met-NCA; Nα-(tert-Butoxycarbonyl)-L-methionine N-carboxyanhydride; (S)-2-((tert-Butoxycarbonyl)amino)-4-(methylthio)butanoic acid 2,5-dioxooxazolidin-4-yl ester; Boc-L-methionine NCA; Boc-Met N-carboxyanhydride; tert-Butoxycarbonylmethionine NCA; BOC-MET-NCA
EINECS	Contact for details

Quality Control

Our Boc-Met-Nca is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	[α]D20: Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.