Description

6-Methyl-4-(4-Nitro-Phenyl)-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and central nervous system disorders. It is essential for research and development chemists, process engineers, and manufacturers in the global pharmaceutical and fine chemical industries who require reliable, high-quality intermediates for scalable production.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel dihydropyrimidine (DHPM) and Biginelli reaction-derived drug candidates.
• API Synthesis: Used in the research and commercial production of Active Pharmaceutical Ingredients (APIs) with potential antihypertensive, calcium channel blocking, and neuroprotective activities.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities in drug discovery programs.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals and complex organic molecules requiring the dihydropyrimidinone core structure.
• Contract Manufacturing (CMO/CDMO): Supplied to contract development and manufacturing organizations for cGMP and non-GMP production of client-specific molecules.

Basic Information

Item	Details
Product Name	6-Methyl-4-(4-Nitro-Phenyl)-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester
CAS No.	161374-08-9
Molecular Formula	C15H15N3O5
Molecular Weight	317.30 g/mol
Synonyms	Ethyl 6-Methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate; 4-(4-Nitrophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid Ethyl Ester; DHPM Nitrophenyl Derivative; Biginelli Adduct; 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic Acid Ethyl Ester; 161374-08-9; Ethyl 4-(4-Nitrophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
EINECS	Contact for details

Quality Control

Our production of 6-Methyl-4-(4-Nitro-Phenyl)-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, and our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.