Description

3-(Difluoromethyl)Aniline Hydrochloride is a high-purity, specialty aromatic amine salt, a key building block in advanced organic synthesis. Its value lies in the unique reactivity of the difluoromethyl-aniline moiety, which is crucial for introducing fluorine-containing pharmacophores into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the difluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced materials with tailored properties.
• Fluorine Chemistry: A valuable reagent for introducing the difluoromethyl group into complex organic frameworks in medicinal and process chemistry.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-(Difluoromethyl)Aniline Hydrochloride
CAS No.	161363-34-4
Molecular Formula	C7H8ClF2N
Molecular Weight	179.59 g/mol
Synonyms	3-(Difluoromethyl)benzenamine hydrochloride; 3-Aminobenzylidene difluoride hydrochloride; m-(Difluoromethyl)aniline hydrochloride; Benzenamine, 3-(difluoromethyl)-, hydrochloride (1:1); 3-(Difluoromethyl)phenylamine hydrochloride; α,α-Difluoro-m-toluidine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Aniline Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.