Description

Fmoc-Dl-Citrulline CAS NO 161125-34-4 is a protected derivative of the non-proteinogenic amino acid citrulline, featuring the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group on the α-amino functionality. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of citrulline residues into complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated, stepwise construction of peptides.
• Peptide Drug Development: Used in the research and production of therapeutic peptides targeting various diseases, where citrullination plays a key biological role.
• Biochemical Research: Serves as a precursor for studying protein citrullination, a crucial post-translational modification involved in epigenetic regulation and autoimmune disorders like rheumatoid arthritis.
• Antibody and Diagnostic Reagent Production: Employed in synthesizing antigens and haptens for generating antibodies specific to citrullinated proteins.
• Organic Synthesis Intermediate: Acts as a chiral synthon for the preparation of more complex, non-peptide molecules in medicinal chemistry.

Basic Information

Product Name	Fmoc-Dl-Citrulline
CAS No.	161125-34-4
Molecular Formula	C₂₁H₂₂N₄O₅
Molecular Weight	410.43 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-DL-citrulline; Fmoc-DL-Cit-OH; Fmoc-DL-Citrulline; Nα-Fmoc-DL-citrulline; (RS)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-5-(carbamoylamino)pentanoic acid; DL-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-5-ureidopentanoic acid; Fmoc-Cit(DL)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-Citrulline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, to ensure it meets the high standards required for peptide synthesis and pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.