Description

5-Pyrimidinecarboxaldehyde, 2,4-Difluoro- (9Ci) is a high-purity, fluorinated pyrimidine derivative building block, essential for advanced organic synthesis. Its core value lies in providing a reactive aldehyde functional group on a difluoropyrimidine scaffold, enabling the construction of complex molecules with precise structural control. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly in medicinal chemistry for drug discovery programs. Its unique structure makes it a valuable precursor for synthesizing potential therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors, antiviral agents, and anticancer compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging the biological activity of the fluorinated pyrimidine core.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized to develop molecular probes and labeled compounds for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Institutional Research: Employed in university and government laboratories for fundamental research in heterocyclic and fluorine chemistry.

Basic Information

Item	Details
Product Name	5-Pyrimidinecarboxaldehyde, 2,4-Difluoro- (9Ci)
CAS No.	161124-04-5
Molecular Formula	C5H2F2N2O
Molecular Weight	144.08 g/mol
Synonyms	2,4-Difluoropyrimidine-5-carboxaldehyde; 2,4-Difluoro-5-formylpyrimidine; 2,4-Difluoropyrimidine-5-carbaldehyde; 5-Formyl-2,4-difluoropyrimidine; 2,4-Difluoro-5-pyrimidinecarboxaldehyde; 2,4-Difluoropyrimidine-5-carboxaldehyde (9CI); 161124-04-5; 2,4-Difluor-5-pyrimidincarbaldehyd
EINECS	Contact for details

Quality Control

Every batch of 5-Pyrimidinecarboxaldehyde, 2,4-Difluoro- (9Ci) is produced and tested under a strict quality management system to ensure high purity, consistency, and traceability. Our standard analytical package includes identification by spectroscopic methods (NMR, IR), purity determination by HPLC, and control of key impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results against agreed specifications. For projects requiring specific regulatory support, we can discuss compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.