Description

2-(2,2,2-Trifluoroethoxy)Phenol is a high-purity fluorinated phenolic compound, serving as a critical building block in advanced chemical synthesis. Its unique trifluoroethoxy substituent imparts valuable properties such as enhanced lipophilicity and metabolic stability, making it indispensable for research and development. This intermediate is primarily sought by the pharmaceutical and agrochemical industries for the creation of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated motifs to modulate bioavailability and potency.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the trifluoroethoxy group can enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated components for liquid crystal displays (LCDs), contributing to improved dielectric anisotropy and stability.
• Polymer Science: Employed as a monomer or modifier in the creation of specialty polymers with tailored surface properties, chemical resistance, and thermal stability.
• Organic Electronics: Investigated as a building block for charge-transport materials, emitters, or host materials in organic light-emitting diodes (OLEDs) and other electronic devices.
• Chemical Research & Development: A versatile reagent for medicinal chemistry and material science R&D, enabling the exploration of structure-activity relationships (SAR).

Basic Information

Product Name	2-(2,2,2-Trifluoroethoxy)Phenol
CAS No.	160968-99-0
Molecular Formula	C8H7F3O2
Molecular Weight	192.14 g/mol
Synonyms	Phenol, 2-(2,2,2-trifluoroethoxy)-; 2-Hydroxyphenyl 2,2,2-trifluoroethyl ether; 1-(2,2,2-Trifluoroethoxy)-2-hydroxybenzene; o-(2,2,2-Trifluoroethoxy)phenol; 2-(Trifluoroethoxy)phenol; 2,2,2-Trifluoroethyl 2-hydroxyphenyl ether
EINECS	Contact for details

Quality Control

Our 2-(2,2,2-Trifluoroethoxy)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.