Description

L-Thiocitrulline Hydrochloride is a high-purity, non-proteinogenic amino acid derivative of significant interest in biochemical research and pharmaceutical development. This compound serves as a crucial building block and a valuable tool for studying nitric oxide synthase (NOS) inhibition and related metabolic pathways. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in advanced peptide synthesis and metabolic studies. The product is supplied with a focus on consistent quality and reliable supply chain integrity for global B2B clients.

Application

• Biochemical Research: Used as a key reagent and substrate analog in enzymatic studies, particularly for investigating the mechanism and inhibition of nitric oxide synthase (NOS) isoforms.
• Pharmaceutical R&D: Serves as a critical intermediate in the synthesis of novel therapeutic peptides and enzyme inhibitors targeting cardiovascular and neurological disorders.
• Metabolomics & Proteomics: Employed as a standard or probe in mass spectrometry and chromatography-based studies of amino acid metabolism and post-translational modifications.
• Fine Chemical Synthesis: Acts as a specialized building block for the custom synthesis of complex, non-natural amino acids and peptide mimetics for drug discovery programs.
• Academic Research: Utilized in university and institutional labs for fundamental studies in biochemistry, cell signaling, and free radical biology.

Basic Information

Product Name	L-Thiocitrulline Hydrochloride
CAS No.	160901-63-3
Molecular Formula	C6H13N3O2S•HCl
Molecular Weight	227.71 g/mol
Synonyms	L-2-Amino-5-(carbamimidamido)pentanoic acid, S-oxide hydrochloride; (S)-2-Amino-5-(carbamimidamido)pentanoic acid 1-oxide hydrochloride; Thiocitrulline HCl; S-Oxo-L-citrulline hydrochloride; L-Thiocitrulline HCl; 160901-63-3; (S)-2-Amino-5-(carbamimidamido)pentanoic acid S-oxide hydrochloride
EINECS	Contact for details

Quality Control

Our L-Thiocitrulline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range available on COA
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.