Description

(Lys9,Trp11,Glu12)-Neurotensin (8-13) (Cyclic Analog) is a synthetic, cyclic peptide analog of the neurotensin C-terminal hexapeptide sequence. This engineered analog offers enhanced metabolic stability and receptor selectivity compared to its linear counterpart, making it a valuable research tool for studying neurotensin receptor (NTS1/NTS2) signaling pathways. It is primarily utilized by researchers and developers in the fields of neuroscience, oncology, and metabolic disorder research for in vitro and in vivo pharmacological studies.

Application

• Neuroscience Research: Used as a selective agonist/antagonist to investigate the role of neurotensin receptors in central nervous system functions, including pain modulation, dopamine signaling, and thermoregulation.
• Oncology Research: Employed in studies exploring the expression and function of neurotensin receptors in various cancer cell lines, particularly pancreatic, prostate, and colon cancers, to understand tumor proliferation and metastasis.
• Drug Discovery & Development: Serves as a critical reference standard and lead compound in the design and screening of novel neurotensin receptor-targeted therapeutics for psychiatric disorders, pain, and cancer.
• Biochemical Assays: Utilized in receptor binding assays, cAMP accumulation tests, and calcium mobilization studies to characterize receptor affinity, potency, and functional activity.
• Metabolic Disorder Studies: Applied in research models to examine the effects of neurotensin on gastrointestinal motility, pancreatic secretion, and lipid metabolism.
• Academic & Pharmaceutical R&D: A key reagent for basic scientific research and preclinical development within university laboratories and pharmaceutical R&D departments globally.

Basic Information

Product Name	(Lys9,Trp11,Glu12)-Neurotensin (8-13) (Cyclic Analog)
CAS No.	160662-16-8
Molecular Formula	C44H60N12O10
Molecular Weight	917.03 g/mol
Synonyms	Cyclic Neurotensin (8-13) analog; [Lys⁹,Trp¹¹,Glu¹²]-NT(8-13); Cyclo(Lys-Lys-Pro-Tyr-Ile-Leu); Neurotensin cyclic analog; NT(8-13) cyclic derivative; H-Cyclo(Lys-Lys-Pro-Tyr-Ile-Leu)-OH; Neurotensin receptor ligand analog
EINECS	Contact for details

Quality Control

Our (Lys9,Trp11,Glu12)-Neurotensin (8-13) (Cyclic Analog) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis to specific purity levels (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.