Description

3-Fluoro-4-Chlorobenzyl Chloride is a versatile and highly reactive halogenated benzyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a functionalized aromatic core that enables the precise introduction of both fluorine and chlorine substituents into target molecules, which is essential for modulating their physical, chemical, and biological properties. This intermediate is particularly vital for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, where its unique substitution pattern is leveraged to fine-tune potency, stability, and metabolic profile.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a starting material for synthesizing fluorinated and chlorinated aromatic compounds used in electronic display technologies.
• Polymer & Resin Modifiers: Incorporated into specialty polymers to impart specific characteristics like flame retardancy, chemical resistance, or altered refractive index.
• Cross-coupling Reactions: An effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures.
• Dye & Pigment Manufacturing: Intermediate in the production of specialized dyes and pigments requiring halogenated aromatic backbones for color fastness and stability.

Basic Information

Product Name	3-Fluoro-4-Chlorobenzyl Chloride
CAS No.	160658-68-4
Molecular Formula	C7H5Cl2F
Molecular Weight	179.02 g/mol
Synonyms	1-(Chloromethyl)-3-fluoro-4-chlorobenzene; 4-Chloro-3-fluorobenzyl Chloride; (3-Fluoro-4-chlorophenyl)methyl Chloride; α-Chloro-3-fluoro-4-chlorotoluene; 3-Fluoro-4-chloro-α-chlorotoluene; 3-Fluoro-4-chlorobenzylchloride; 4-Chloro-3-fluoro-benzylchloride; Benzenemethanol, 4-chloro-3-fluoro-, chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-Chlorobenzyl Chloride is produced and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency meet the exacting standards required for fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Density (at 20°C)	~1.4 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.