Description

(D-Ala3)-Dynorphin A (1-11) Amide CAS NO 160522-58-7 is a synthetic, biologically active peptide analog of the endogenous opioid peptide dynorphin A. This compound is of significant value in neuroscience and pharmacological research due to its selective interaction with κ-opioid receptors (KOR). It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies for applications in neurobiological studies, receptor binding assays, and the development of novel analgesic or neuropsychiatric therapeutics.

Application

• Neuroscience Research: Used as a selective κ-opioid receptor (KOR) agonist to study pain pathways, addiction mechanisms, and mood disorders.
• Pharmacological Assays: Serves as a reference standard in competitive binding and functional assays (e.g., cAMP accumulation, GTPγS binding) to characterize receptor activity.
• Drug Discovery: A key tool compound for screening and developing new analgesic or neuroprotective agents targeting the opioid system.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to understand the impact of D-amino acid substitution on peptide stability and receptor selectivity.
• In vitro & Ex vivo Models: Applied in tissue bath experiments and cell-based models to investigate KOR-mediated physiological responses.

Basic Information

Product Name	(D-Ala3)-Dynorphin A (1-11) Amide
CAS No.	160522-58-7
Molecular Formula	C61H94N18O14
Molecular Weight	1279.5 g/mol
Synonyms	Dynorphin A (1-11) amide, [D-Ala3]-; [D-Ala3]-Dynorphin A (1-11)NH2; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-NH2 (with D-Ala at position 3); (D-Alanine3)-Dynorphin A(1-11) amide; D-Ala3-Dynorphin A (1-11); Kappa opioid receptor agonist peptide; Dynorphin A fragment (1-11) analog
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of (D-Ala3)-Dynorphin A (1-11) Amide is characterized by advanced analytical techniques including HPLC, MS, and amino acid analysis to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.