Description

n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-o-[3,4,6-Tri-o-Acetyl-2-(Acetylamino)-2-Deoxy-β-D-Glucopyranosyl]-L-Serine Pentafluorophenyl Ester is a sophisticated, protected glycosylated amino acid derivative, specifically designed as a key building block for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers developing glycopeptides, which are essential in advanced pharmaceutical research for creating targeted therapeutics and vaccines. It is primarily utilized by pharmaceutical R&D laboratories and biotechnology companies focused on oncology, immunology, and metabolic disease research.

Application

• Glycopeptide Synthesis: A crucial activated ester intermediate for the controlled incorporation of O-linked N-acetylglucosamine (O-GlcNAc) serine residues into peptide chains.
• Pharmaceutical Research: Used in the development of novel glycopeptide-based drug candidates, including anticancer agents, antibiotics, and hormone analogs.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled glycopeptides or glycoprotein mimics used in biochemical assays and diagnostic tool development.
• Academic Research: Fundamental studies in glycoscience, chemical biology, and post-translational modification (PTM) mechanisms.
• Process Development: Scaling up the production of specific therapeutic glycopeptides under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-o-[3,4,6-Tri-o-Acetyl-2-(Acetylamino)-2-Deoxy-β-D-Glucopyranosyl]-L-Serine Pentafluorophenyl Ester
CAS No.	160410-57-1
Molecular Formula	C₃₈H₃₇F₅N₂O₁₂
Molecular Weight	808.71 g/mol
Synonyms	Fmoc-Ser(Ac₃-β-D-GlcNAc)-OPfp; Fmoc-Ser[Ac₃-β-D-GlcNAc(Ac)₃]-OPfp Ester; Fmoc-O-(3,4,6-Tri-O-acetyl-2-acetamido-2-deoxy-β-D-glucopyranosyl)-L-serine pentafluorophenyl ester; N-α-Fmoc-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-serine pentafluorophenyl ester; Glycosylated Fmoc-Serine OPfp Ester; O-GlcNAc(Fmoc-Ser-OPfp) peracetate; Building block for glycopeptide synthesis; Fmoc-Ser(GlcNAc(Ac)₃)-OPfp
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical building block adheres to stringent quality protocols. Every batch is characterized and tested to ensure identity, purity, and consistency, critical for reproducible results in sensitive peptide synthesis. Analysis is performed via HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and moisture content is provided with each shipment to support your quality management system.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.