Description

Fmoc-L-Thr(β-D-Glcnac(Ac)3)-Oh is a sophisticated, protected amino acid derivative essential for advanced solid-phase peptide synthesis (SPPS). This compound is specifically designed for the controlled incorporation of O-linked N-acetylglucosamine (O-GlcNAc) moieties into synthetic peptides and glycopeptides, enabling critical research in post-translational modifications. It is a vital building block for pharmaceutical researchers, medicinal chemists, and biochemists working in drug discovery, proteomics, and the development of therapeutic glycopeptides and biologics.

Application

• Glycopeptide Synthesis: A key protected intermediate for the chemical synthesis of O-GlcNAcylated peptides, mimicking natural post-translational modifications.
• Pharmaceutical R&D: Used in the discovery and development of novel glycopeptide-based therapeutics, including potential anti-cancer and anti-inflammatory agents.
• Biochemical Research: Essential for studying the role of O-GlcNAcylation in cellular signaling, transcription, and disease pathology (e.g., diabetes, neurodegenerative disorders).
• Medicinal Chemistry: Serves as a building block for creating libraries of glycopeptide analogs for structure-activity relationship (SAR) studies.
• Proteomics Tool Development: Used to synthesize standardized glycopeptide probes and standards for mass spectrometry and analytical method development.
• Bioconjugation: Can be utilized in the site-specific modification of proteins and other biomolecules with defined glycan structures.

Basic Information

Product Name	Fmoc-L-Thr(β-D-Glcnac(Ac)3)-Oh
CAS No.	160168-40-1
Molecular Formula	C₃₈H₄₈N₂O₁₇
Molecular Weight	828.80 g/mol
Synonyms	Fmoc-Thr(GlcNAc(Ac)3)-OH; N-α-Fmoc-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-threonine; Fmoc-L-threonine, O-[2-(acetylamino)-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl]-; Fmoc-Thr[β-D-GlcNAc(Ac)₃]-OH; Fmoc-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)threonine; Fmoc-T(GlcNAc(Ac)3)-OH; Fmoc-L-Thr(β-D-GlcNAc(Ac)₃)-OH; Protected Fmoc-Threonine-GlcNAc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-L-Thr(β-D-Glcnac(Ac)3)-Oh is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support pre-clinical and development-phase pharmaceutical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, maintain under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0% (Area Percent)
Assay	≥90.0% (by quantitative NMR or HPLC)
Water Content (KF)	≤1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.