Description

Fmoc-Lys(Biotinyl-E-Aminocaproyl)-Oh is a sophisticated, multi-functional amino acid derivative designed for advanced bioconjugation and peptide synthesis. This compound integrates a biotin tag via a flexible aminocaproyl linker onto an Fmoc-protected lysine residue, enabling high-affinity capture and detection in biochemical assays. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic kit production who require precise, site-specific labeling of biomolecules. The product offers a reliable solution for creating stable, biotinylated peptides and proteins with minimal steric hindrance.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is directly incorporated into custom peptide sequences during automated synthesis.
• Avidin/Biotin Technology: Serves as a key reagent for introducing biotin tags into peptides for purification, immobilization, or detection using streptavidin/avidin systems.
• Diagnostic Assay Development: Used to create biotinylated antigens, antibodies, or probes for ELISA, lateral flow tests, and other immunoassay platforms.
• Proteomics and Protein Interaction Studies: Enables the labeling of proteins to study protein-protein interactions, pull-down assays, and affinity chromatography.
• Drug Discovery & ADC Development: Facilitates the construction of biotin-drug conjugates for screening or as intermediates in the synthesis of Antibody-Drug Conjugates (ADCs).
• Biomaterial and Surface Functionalization: Used to modify surfaces with biotinylated peptides for creating bioactive coatings or sensor chips.

Basic Information

Product Name	Fmoc-Lys(Biotinyl-E-Aminocaproyl)-Oh
CAS No.	160158-05-4
Molecular Formula	C46H65N7O9S
Molecular Weight	892.12 g/mol
Synonyms	Fmoc-Lys(Biotin-LC)-OH; Nα-Fmoc-Nε-(biotinyl-6-aminocaproyl)-L-lysine; Fmoc-Lys(Biotinyl-ε-aminocaproyl)-OH; Fmoc-Lys(Biotin-X)-OH; Biotinyl-6-aminocaproyl-Fmoc-Lys-OH; Fmoc-L-lysine(Biotinyl-6-aminocaproyl); Fmoc-Lys(Biotin-AC)-OH; Fmoc-Lys(Biotinyl-ε-Ahx)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Biotinyl-E-Aminocaproyl)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure structural integrity and enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data, ensuring full traceability and compliance with research and cGMP-grade material expectations for preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.