Description

n-Fmoc-5-Aminolevulinic Acid is a key protected derivative of 5-aminolevulinic acid (5-ALA), a crucial biosynthetic precursor in the heme and chlorophyll pathways. This compound is specifically engineered to provide a stable, reactive intermediate for advanced organic synthesis, particularly in peptide and complex molecule construction. It is an essential building block for researchers and manufacturers in pharmaceutical development, agrochemical research, and life science applications requiring precise molecular assembly.

Application

• Pharmaceutical Intermediate: Serves as a critical protected synthon in the synthesis of porphyrin-based drugs, including photodynamic therapy (PDT) agents and diagnostic compounds.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) where the Fmoc group provides orthogonal protection for the amine functionality of 5-ALA.
• Biochemical Research: A vital tool in studying the biosynthesis of heme, chlorophyll, and vitamin B12, enabling controlled manipulation of the tetrapyrrole pathway.
• Agrochemical Development: Employed in the research and synthesis of novel herbicides and plant growth regulators that target the porphyrin biosynthesis pathway in plants.
• Pro-drug Synthesis: Utilized in the design and creation of pro-drugs that metabolize to release active 5-aminolevulinic acid for therapeutic purposes.
• Chemical Biology Probes: Acts as a building block for creating labeled or modified porphyrins used as probes in cellular imaging and mechanistic studies.

Basic Information

Product Name	n-Fmoc-5-Aminolevulinic Acid
CAS No.	160111-41-1
Molecular Formula	C₂₀H₁₉NO₆
Molecular Weight	369.37 g/mol
Synonyms	5-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-4-oxopentanoic Acid; Fmoc-5-ALA; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-aminolevulinic Acid; 5-[(Fmoc)amino]levulinic Acid; 4-Oxo-5-[(9H-fluoren-9-ylmethoxycarbonyl)amino]pentanoic Acid; Fmoc-ALA-OH (5-Aminolevulinic Acid derivative); N-Fmoc-δ-aminolevulinic acid; 5-(Fmoc-amino)-4-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-5-Aminolevulinic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific pharmacopeial or customer-specific requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.