Description

(S)-2-((S)-2-Amino-3-Methylbutanamido)-5-Ureidopentanoic Acid is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical research and development. Its defined stereochemistry and unique functional groups make it a valuable chiral building block for the synthesis of complex peptides and peptidomimetics. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including enzyme inhibitors and receptor modulators. The CAS number for this compound is 159858-33-0.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used as a specialized amino acid residue in solid-phase and solution-phase peptide synthesis to introduce structural complexity.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and structure-activity relationship (SAR) investigations.
• Proteomics & Drug Discovery: Employed in the design and development of peptide-based therapeutics, diagnostics, and chemical probes.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	(S)-2-((S)-2-Amino-3-Methylbutanamido)-5-Ureidopentanoic Acid
CAS No.	159858-33-0
Molecular Formula	C11H22N4O4
Molecular Weight	274.32 g/mol
Synonyms	L-Valyl-L-citrulline; H-Val-Cit-OH; N2-[(2S)-2-Amino-3-methylbutanoyl]-N5-carbamoyl-L-ornithine; Val-Cit; VC-PABA linker precursor; ADC Linker Amino Acid; (2S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-5-(aminocarbonylamino)pentanoic acid
EINECS	Contact for details

Quality Control

Our (S)-2-((S)-2-Amino-3-Methylbutanamido)-5-Ureidopentanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.