Description

Melagatran is a direct thrombin inhibitor, representing a significant class of anticoagulant agents. Its primary value lies in its ability to prevent blood clot formation by directly and reversibly binding to thrombin, a key enzyme in the coagulation cascade. This compound is of critical importance to the pharmaceutical research and development sector, particularly for scientists developing novel antithrombotic therapies. Professionals in medicinal chemistry, pharmacology, and process development require high-purity Melagatran CAS NO 159776-70-2 for preclinical studies, analytical method development, and formulation research.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and analytical method validation in drug manufacturing and regulatory testing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic intermediate in the production of advanced anticoagulant drugs, such as ximelagatran.
• Biochemical Research: Employed in in vitro studies to investigate thrombin inhibition mechanisms, coagulation pathways, and structure-activity relationships (SAR).
• Preclinical Development: Utilized in animal models to assess the pharmacokinetics, efficacy, and safety profiles of next-generation antithrombotic agents.
• Analytical Chemistry: Acts as a critical component for developing and calibrating high-performance liquid chromatography (HPLC) and mass spectrometry (MS) assays.

Basic Information

Product Name	Melagatran
CAS No.	159776-70-2
Molecular Formula	C19H32N6O4
Molecular Weight	408.50 g/mol
Synonyms	H 376/95; H-376/95; H37695; (2S)-2-{[(3R)-3-Amino-2-oxo-1-pyrrolidinyl]methyl}-4-{[(3S)-3-(diaminomethylideneamino)-2-oxo-1-pyrrolidinyl]methyl}pentanedioic acid; (2S)-2-[[(3R)-3-Amino-2-oxo-1-pyrrolidinyl]methyl]-4-[[(3S)-3-(diaminomethyleneamino)-2-oxo-1-pyrrolidinyl]methyl]pentanedioic acid; Melagatran (H 376/95)
EINECS	Contact for details

Quality Control

Our Melagatran is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Quality is verified through comprehensive analytical testing, including HPLC for purity, chiral methods for stereochemical integrity, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each batch, documenting compliance with agreed specifications. We support development projects requiring material that meets ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.