Description

n-Fmoc-N'-Boc-D-Histidine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This high-purity building block is critical for researchers and manufacturers requiring precise chirality and side-chain protection in complex molecule assembly. It is primarily utilized in pharmaceutical R&D for the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of D-histidine into peptide chains.
• Pharmaceutical Research: Building block for the discovery and development of peptide drugs, hormones, and enzyme inhibitors.
• Combinatorial Chemistry Libraries: Used to create diverse arrays of compounds for high-throughput screening in drug discovery.
• Bioconjugation: Serves as a precursor for labeling peptides or creating peptide-protein conjugates for diagnostic applications.
• Asymmetric Synthesis: Employed in the synthesis of chiral catalysts or complex natural product analogs.
• Academic & Institutional Research: Fundamental reagent for studying peptide structure, function, and bioactivity.

Basic Information

Product Name	n-Fmoc-N'-Boc-D-Histidine
CAS No.	159631-28-4
Molecular Formula	C₂₆H₂₉N₃O₆
Molecular Weight	479.53 g/mol
Synonyms	Fmoc-His(Boc)-OH (D-form); D-Fmoc-His(Boc)-OH; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]imidazol-4-yl]propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-[(1,1-dimethylethoxy)carbonyl]-D-histidine; D-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-[(1,1-dimethylethoxy)carbonyl]-; Fmoc-D-His(Boc)-OH; Boc-D-His(Fmoc)-OH; FMOC-HIS(BOC)-D-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-N'-Boc-D-Histidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.