Description

H-L-Lys(N3)-Oh*Hci is a chemically modified amino acid derivative, specifically an azide-functionalized lysine hydrochloride salt. This compound serves as a critical building block in advanced bioconjugation and click chemistry applications, enabling the precise and efficient labeling of biomolecules. It is essential for researchers and manufacturers in the fields of pharmaceutical development, proteomics, and diagnostic reagent production, where site-specific modification of peptides and proteins is required.

Application

• Peptide Synthesis & Modification: A key intermediate for introducing azide functional groups into peptide chains for subsequent bioorthogonal conjugation.
• Bioconjugation & Click Chemistry: Used in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to label proteins, antibodies, and other biomolecules with fluorescent dyes, drugs, or polymers.
• Chemical Biology Research: Enables the study of protein function, localization, and interactions through site-specific tagging in live cells or in vitro systems.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the construction of stable, homogeneous linkers between monoclonal antibodies and potent cytotoxic agents.
• Diagnostic Assay Development: Used to create labeled antigens or antibodies for immunoassays, flow cytometry, and imaging applications.
• Material Science & Surface Functionalization: Applied to modify surfaces with bioactive peptides for tissue engineering, biosensor development, and biomaterial research.

Basic Information

Product Name	H-L-Lys(N3)-Oh*Hci
CAS No.	159610-92-1
Molecular Formula	C6H13N5O2 • HCl
Molecular Weight	223.66 g/mol (Free base) / 260.12 g/mol (Hydrochloride)
Synonyms	N6-Azido-L-lysine hydrochloride; Nε-Azido-L-lysine HCl; L-Lysine, N6-azido-, hydrochloride; Azido-L-lysine hydrochloride; (2S)-2-Amino-6-azidohexanoic acid hydrochloride; Fmoc-Lys(N3)-OH•HCl (precursor); Click chemistry lysine derivative; 159610-92-1
EINECS	Contact for details

Quality Control

Our H-L-Lys(N3)-Oh*Hci is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (by HPLC), and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.