Description

Fmoc-Lys(N3)-Oh is a specialized, azide-functionalized amino acid derivative designed for advanced peptide synthesis and bioconjugation. This compound is a critical building block in the development of complex biomolecules, enabling the site-specific introduction of functional groups via click chemistry. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the creation of novel drug delivery systems and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled, sequential assembly of peptides, particularly those requiring orthogonal protection strategies.
• Bioconjugation and Labeling: Enables efficient, copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click" reactions to attach fluorophores, polymers, or other molecules to peptides and proteins.
• Chemical Biology and Proteomics: Used to synthesize activity-based probes (ABPs) and affinity tags for studying enzyme function and protein-protein interactions.
• Drug Discovery: Facilitates the synthesis of peptide-drug conjugates (PDCs) and other therapeutic candidates with tailored pharmacokinetic properties.
• Material Science: Serves as a monomer for creating functionalized biomaterials, hydrogels, and surfaces with bioactive properties.
• Antibody-Drug Conjugate (ADC) Development: Provides a handle for the precise, site-specific attachment of cytotoxic payloads to antibodies.

Basic Information

Product Name	Fmoc-Lys(N3)-Oh
CAS No.	159610-89-6
Molecular Formula	C21H21N5O4
Molecular Weight	407.43 g/mol
Synonyms	Fmoc-L-lysine(N3)-OH; N6-Azido-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine; Fmoc-Lys(N3)-OH; Nα-Fmoc-Nε-azido-L-lysine; Fmoc-Lys(Azide)-OH; (2S)-6-Azido-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]hexanoic acid; Fmoc-L-azidolysine-OH; Fmoc-Lys(N3)
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(N3)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.