Description

(D-Ala7)-Angiotensin I/II (1-7) is a synthetic peptide analog of the endogenous angiotensin fragments, characterized by the substitution of a D-alanine residue at position 7, which confers enhanced metabolic stability. This modification makes it a critical research tool for studying the renin-angiotensin system (RAS), particularly the roles of angiotensin (1-7) and its receptor Mas in cardiovascular physiology and pathophysiology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular drug discovery, metabolic studies, and peptide biochemistry.

Application

• Biomedical Research: As a stable analog for investigating the vasodilatory, anti-fibrotic, and anti-inflammatory pathways mediated by the angiotensin-(1-7)/Mas receptor axis.
• Drug Discovery & Development: Serving as a reference standard or a lead compound in the design of novel therapeutics targeting hypertension, heart failure, and renal diseases.
• Biochemical Assays: Used in receptor binding studies, enzyme activity assays (e.g., ACE2), and functional cellular assays to elucidate signaling mechanisms.
• In Vitro & In Vivo Studies: Employed in preclinical models to study cardiovascular protection, metabolic effects, and potential therapeutic applications.
• Quality Control: Acting as a high-purity standard for the calibration of analytical instruments (HPLC, MS) in peptide manufacturing and quality assurance laboratories.

Basic Information

Item	Detail
Product Name	(D-Ala7)-Angiotensin I/II (1-7)
CAS No.	159432-28-7
Molecular Formula	C41H62N12O11
Molecular Weight	898.99 g/mol
Synonyms	Angiotensin (1-7) (D-Ala7); Asp-Arg-Val-Tyr-Ile-His-D-Ala; [D-Ala7]-Angiotensin I/II (1-7); DRVYIHDa; (D-Ala7)-Ang (1-7); Angiotensin 1-7 D-Ala7 analog; H-Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH
EINECS	Contact for details

Quality Control

Our (D-Ala7)-Angiotensin I/II (1-7) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, and specifications can be tailored to meet specific project requirements. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.