Description

2,2,3,3-Tetrafluoro-1,4-benzodioxene-6-carbaldehyde is a specialized fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the aldehyde group combined with the electronic and steric properties imparted by the tetrafluorobenzodioxene scaffold, enabling the construction of complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel fluorinated intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting CNS disorders and inflammation, where the fluorinated moiety can enhance metabolic stability and bioavailability.
• Agrochemical Research: Used in the synthesis of advanced herbicide and pesticide candidates, leveraging the fluorine atoms to improve lipophilicity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated electron-transport materials, host materials, and ligands in organic light-emitting diodes (OLEDs) and display technologies.
• Polymer & Specialty Chemicals: Employed as a monomer or cross-linking agent for developing high-performance, fluorinated polymers with enhanced thermal and chemical resistance.
• Catalyst & Ligand Synthesis: Utilized to construct sophisticated, fluorinated ligands for transition metal catalysis, enabling new asymmetric transformations.
• Academic & Contract Research: A valuable tool for methodological studies in organic chemistry, particularly in cross-coupling and nucleophilic addition reactions involving fluorinated arenes.

Basic Information

Product Name	2,2,3,3-Tetrafluoro-1,4-benzodioxene-6-carbaldehyde
CAS No.	159276-63-8
Molecular Formula	C9H2F4O3
Molecular Weight	234.11 g/mol
Synonyms	6-Formyl-2,2,3,3-tetrafluoro-1,4-benzodioxene; 2,2,3,3-Tetrafluoro-1,4-benzodioxin-6-carboxaldehyde; 1,4-Benzodioxene-6-carboxaldehyde, 2,2,3,3-tetrafluoro-; Tetrafluorobenzodioxene carbaldehyde; 6-Carbaldehyde-2,2,3,3-tetrafluoro-1,4-benzodioxene; 159276-63-8; 2,2,3,3-Tetrafluoro-1,4-benzodioxin-6-carbaldehyde
EINECS	Contact for details

Quality Control

Our 2,2,3,3-Tetrafluoro-1,4-benzodioxene-6-carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (1H & 19F NMR)
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.