Description

D-Proline, 4-Hydroxy-5-(Hydroxymethyl)-, (4R,5S)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry at the 4 and 5 positions. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the production of complex molecules with precise stereochemical control. It is essential for research and development in the pharmaceutical industry, particularly for the synthesis of novel active pharmaceutical ingredients (APIs), prodrugs, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel therapeutics, including enzyme inhibitors and receptor modulators.
• Asymmetric Synthesis: Utilized as a building block or chiral auxiliary in stereoselective chemical reactions to construct complex molecular architectures.
• Peptidomimetics & Drug Design: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and target specificity.
• Bioconjugation & Linker Chemistry: Used in the development of antibody-drug conjugates (ADCs) and other bioconjugates due to its functional handles.
• Catalyst & Ligand Development: Serves as a precursor for designing novel chiral ligands and organocatalysts for industrial catalytic processes.
• Biochemical Research: Employed as a standard or probe in enzymatic studies and metabolic pathway analysis.

Basic Information

Product Name	D-Proline, 4-Hydroxy-5-(Hydroxymethyl)-, (4R,5S)- (9Ci)
CAS No.	159247-18-4
Molecular Formula	C6H11NO4
Molecular Weight	161.16 g/mol
Synonyms	(4R,5S)-4-Hydroxy-5-(hydroxymethyl)-D-proline; (2S,4R,5S)-4-Hydroxy-5-(hydroxymethyl)proline; 4-Hydroxy-5-(hydroxymethyl)-D-proline; D-4-Hydroxy-5-(hydroxymethyl)proline; (4R,5S)-4-Hydroxy-5-(hydroxymethyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Hydroxy-5-(Hydroxymethyl)-, (4R,5S)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and absence of specified impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.