Description

Cariporide is a potent and selective inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE-1), a key regulator of intracellular pH and sodium homeostasis. This compound is of significant interest in cardiovascular and ischemia-reperfusion injury research due to its cardioprotective properties. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on developing novel therapeutics for myocardial infarction and related cardiac conditions.

Application

• Cardiovascular Research: A critical tool for studying the role of NHE-1 in cardiac ischemia, reperfusion injury, and myocardial infarction models.
• Pharmacological Studies: Used to investigate the cardioprotective mechanisms of NHE-1 inhibition and to evaluate potential therapeutic candidates.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) assays targeting the NHE-1 transporter.
• Preclinical Drug Development: Employed in animal studies to validate the efficacy of NHE-1 inhibition as a strategy for reducing infarct size and improving cardiac function post-ischemia.
• Mechanistic Cell Biology: Used to probe intracellular pH regulation, sodium-calcium exchange, and cell volume control in various cell types under stress conditions.

Basic Information

Product Name	Cariporide
CAS No.	159138-80-4
Molecular Formula	C20H26N4O3S
Molecular Weight	402.51 g/mol
Synonyms	HOE 642; 4-Isopropyl-3-methylsulfonylbenzoyl-guanidine methanesulfonate; 3-Methylsulfonyl-4-(propan-2-yl)benzoylguanidine methanesulfonate; Cariporide mesylate; NHE-1 Inhibitor HOE 642
EINECS	Contact for details

Quality Control

Our Cariporide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.