Description

2-(Boc-Amino)-3-(Fmoc-Amino)Propionic Acid is a specialized, dual-protected amino acid derivative essential for advanced peptide synthesis. This compound is critically valued for its orthogonal protecting groups, which allow for selective deprotection and the sequential construction of complex peptide chains. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of peptide-based therapeutics, diagnostics, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential addition of amino acids, particularly useful for synthesizing peptides containing difficult sequences or modified residues.
• Solution-Phase Peptide Synthesis: Employed in the synthesis of medium to long-chain peptides and small proteins where orthogonal protection strategies are required.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and production of peptide drugs, including hormone analogs, antimicrobial peptides, and targeted cancer therapies.
• Combinatorial Chemistry Libraries: Used to generate diverse arrays of peptide-like compounds for high-throughput screening in drug discovery programs.
• Bioconjugation and Probe Development: Facilitates the site-specific introduction of functional handles (via the carboxylic acid group) for labeling peptides with fluorophores, biotin, or other reporter molecules.
• Academic and Industrial Research: A fundamental reagent for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	2-(Boc-Amino)-3-(Fmoc-Amino)Propionic Acid
CAS No.	159002-16-1
Molecular Formula	C23H26N2O6
Molecular Weight	426.47 g/mol
Synonyms	Boc-β-(Fmoc-amino)-Ala-OH; Nα-Boc-Nβ-Fmoc-2,3-diaminopropionic Acid; (2R/S)-2-[(tert-Butoxycarbonyl)amino]-3-[(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic Acid; Fmoc-Dap(Boc)-OH; Boc-Dap(Fmoc)-OH; 2,3-Diaminopropionic Acid, Nα-Boc, Nβ-Fmoc; DL-2-(Boc-amino)-3-(Fmoc-amino)propionic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-(Boc-Amino)-3-(Fmoc-Amino)Propionic Acid is manufactured and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for pharmaceutical research and peptide synthesis. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.