Description

(n-Me-D-Phe7)-Bradykinin CAS NO 158873-14-4 is a synthetic, site-specifically modified analog of the endogenous peptide hormone bradykinin. This engineered compound is significant for its enhanced metabolic stability and receptor selectivity, making it a critical tool for advanced pharmacological research. It is primarily needed by pharmaceutical R&D laboratories, academic institutions, and biotech companies focused on cardiovascular research, inflammation studies, and the development of novel peptide-based therapeutics.

Application

• Pharmacological Research: Used as a stable reference standard and probe for studying bradykinin B1 and B2 receptor signaling pathways and functions.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the design of new anti-inflammatory, analgesic, and cardiovascular drugs.
• Biochemical Assays: Employed in enzyme inhibition studies, receptor binding assays (e.g., radioligand binding), and cellular response characterization.
• Metabolic Stability Studies: Utilized to investigate the structure-activity relationships (SAR) and degradation profiles of modified peptide sequences.
• Academic & Clinical Research: Applied in fundamental research exploring the role of the kallikrein-kinin system in pain, inflammation, and blood pressure regulation.
• Peptide Chemistry Reference: Acts as a model compound for studying the synthesis, purification, and analysis of N-methylated and D-amino acid substituted peptides.

Basic Information

Product Name	(n-Me-D-Phe7)-Bradykinin
CAS No.	158873-14-4
Molecular Formula	C58H85N15O12
Molecular Weight	1160.4 g/mol
Synonyms	N-Methyl-D-phenylalanine(7)-bradykinin; [D-Phe7, N-Me-Phe8]-Bradykinin; H-Arg-Pro-Pro-Gly-Phe-Ser-D-Phe-N-Me-Phe-Arg-OH; Bradykinin, 7-(N-methyl-D-phenylalanine)-; Modified Bradykinin Analog; BK (1-9), D-Phe7, N-Me-Phe8; Kinin B2 Receptor Selective Analog
EINECS	Contact for details

Quality Control

Every batch of (n-Me-D-Phe7)-Bradykinin is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, HPLC chromatograms, and mass spectrometry data are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.