Description

Fmoc-Tyr(Po3(Mdpse)2)-Oh is a specialized, orthogonally protected phosphotyrosine mimetic building block used in solid-phase peptide synthesis (SPPS). This compound is critical for introducing stable, non-hydrolyzable phosphonate groups that mimic phosphorylated tyrosine residues, enabling the study of protein-protein interactions and signal transduction pathways. It is an essential reagent for pharmaceutical researchers and peptide chemists developing therapeutic peptides, diagnostic tools, and biochemical probes targeting phosphorylation-dependent processes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the incorporation of phosphotyrosine analogs into custom peptide sequences.
• Phosphoproteomics Research: For synthesizing stable phosphopeptide standards and affinity ligands to study kinase and phosphatase activity.
• Drug Discovery: In the development of peptide-based inhibitors that target SH2 domains, PTB domains, and other phosphotyrosine-binding modules involved in cancer and inflammatory diseases.
• Bioconjugation: Used to create chemically defined, phosphorylated peptide conjugates for antibody production, assay development, and diagnostic applications.
• Chemical Biology Tool Development: For generating cell-permeable peptides and activity-based probes to interrogate intracellular signaling networks.

Basic Information

Product Name	Fmoc-Tyr(Po3(Mdpse)2)-Oh
CAS No.	158817-11-9
Molecular Formula	C₃₈H₄₀N₂O₁₀P₂S₂
Molecular Weight	810.81 g/mol
Synonyms	Fmoc-Tyr(PO3H2)-OH (Mdpse)2; N-α-Fmoc-O-[bis(2,2-dimethyl-2-sulfoethyl)phosphono]-L-tyrosine; Fmoc-L-Tyrosine(PO3H2) bis(2,2-dimethyl-2-sulfoethyl) ester; Fmoc-Tyr(PO3H2)-OH DMSO-sulfone protected; Fmoc-Tyr[PO(OCH2C(CH3)2SO2CH2CH3)2]-OH; Phosphotyrosine Mimetic, Fmoc-protected; Fmoc-O-(diethylphosphono)-L-tyrosine analog
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(Po3(Mdpse)2)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive peptide synthesis and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.