Description

Fmoc-Tryptophanol CAS NO 158815-60-2 is a protected amino alcohol derivative, specifically the Fmoc-protected form of tryptophanol. This compound serves as a crucial chiral building block and intermediate in modern organic synthesis, particularly in the construction of complex peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of the tryptophan side chain with an alcohol functional group into peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) and drug candidates, especially those targeting neurological and oncological pathways.
• Peptidomimetic Design: Essential for creating non-peptide compounds that mimic the structure and function of natural peptides, improving metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthesis due to its inherent chirality.
• Combinatorial Chemistry: A valuable building block for generating diverse chemical libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-Tryptophanol
CAS No.	158815-60-2
Molecular Formula	C26H24N2O3
Molecular Weight	412.48 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tryptophanol; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-indol-3-yl)propan-1-ol; Fmoc-Trp-ol; Fmoc-L-Tryptophanol; N-Fmoc-L-tryptophanol; 1H-Indole-3-propanol, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (αS)-; Fmoc-Tryptophan-ol
EINECS	Contact for details

Quality Control

Our Fmoc-Tryptophanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.