Description

Cyclo(-Gly-Tyr(Po3H2)-Val-Pro-Met-Leu) is a synthetic, cyclic peptide featuring a phosphorylated tyrosine residue, which is critical for modulating biological activity. This compound is of significant interest for advanced biochemical research and pharmaceutical development due to its role in studying signal transduction pathways and protein-protein interactions. It is primarily utilized by researchers in academia, biotechnology, and pharmaceutical R&D for investigating kinase and phosphatase mechanisms, as well as for developing novel therapeutic agents.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in enzymatic studies of protein kinases and phosphatases.
• Signal Transduction Studies: Employed to probe and modulate intracellular signaling cascades involving tyrosine phosphorylation.
• Drug Discovery: Serves as a key intermediate or lead compound in the development of targeted cancer therapies and other disease-modifying drugs.
• Proteomics & Peptide Library Screening: Incorporated into peptide arrays for high-throughput screening to identify binding partners or enzyme specificity.
• Antibody Development: Acts as a hapten for generating phospho-specific antibodies used in diagnostic and research applications.
• Cell Biology Assays: Utilized in cell-based assays to study the effects of phosphorylated peptides on cellular functions like proliferation and apoptosis.

Basic Information

Product Name	Cyclo(-Gly-Tyr(Po3H2)-Val-Pro-Met-Leu)
CAS No.	158778-21-3
Molecular Formula	C32H48N8O12PS
Molecular Weight	793.82 g/mol
Synonyms	Cyclo(Gly-O-phospho-Tyr-Val-Pro-Met-Leu); c(Gly-pTyr-Val-Pro-Met-Leu); Cyclic Glycyl-O-phosphotyrosyl-valyl-prolyl-methionyl-leucine; Phosphotyrosine-containing cyclic hexapeptide; pTyr Cyclic Peptide; CAS 158778-21-3
EINECS	Contact for details

Quality Control

Our Cyclo(-Gly-Tyr(Po3H2)-Val-Pro-Met-Leu) is manufactured under strict quality systems suitable for research and development. Each batch undergoes comprehensive analytical characterization including HPLC for purity, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solvent Content (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.