Description

2-Methoxy-4-(Trifluoromethyl)Aniline is a versatile aromatic amine building block characterized by its methoxy and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group contributes to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-transport materials and alignment layers in display technologies.
• Dye & Pigment Manufacturing: Employed in the synthesis of specialized azo dyes and high-performance pigments.
• Polymer Modification: Acts as a functional monomer or cross-linking agent to introduce specific properties into polymer chains.
• Chemical Research & Development: A valuable reagent for methodological studies in organic synthesis, including cross-coupling and amination reactions.

Basic Information

Product Name	2-Methoxy-4-(Trifluoromethyl)Aniline
CAS No.	158727-56-1
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	4-Amino-3-methoxybenzotrifluoride; 2-Methoxy-4-(trifluoromethyl)benzenamine; 3-Methoxy-4-aminobenzotrifluoride; 4-(Trifluoromethyl)-2-methoxyaniline; 2-Methoxy-α,α,α-trifluoro-p-toluidine; 4-Amino-3-methoxy-α,α,α-trifluorotoluene; 2-Methoxy-4-trifluoromethylaniline; 2-Methoxy-4-(trifluoromethyl)phenylamine
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.