Description

Fibronectin Fragment (1376-1380) is a synthetic pentapeptide sequence derived from the cell-binding domain of human fibronectin. This specific fragment is a critical research tool for studying cell adhesion, migration, and signaling pathways mediated by integrin receptors. It is essential for researchers and developers in the fields of biomedical research, drug discovery, and tissue engineering. The compound is supplied as a high-purity material to ensure reliable and reproducible experimental results.

Application

• Biochemical Research: Used as a standard or active component in studies investigating integrin-ligand interactions, cell adhesion mechanisms, and extracellular matrix biology.
• Drug Discovery Screening: Serves as a target or inhibitor in high-throughput assays to identify novel therapeutic compounds that modulate cell adhesion processes.
• Cell Culture & Tissue Engineering: Coated onto surfaces to promote specific cell attachment, spreading, and differentiation for advanced in vitro models and scaffold functionalization.
• Antagonist Studies: Employed to competitively inhibit native fibronectin binding to integrins, helping to elucidate the functional role of specific binding sites in physiological and pathological states.
• Biomaterial Development: Incorporated into synthetic polymers or hydrogels to create bioactive materials that mimic the natural cellular environment.
• Standard for Analytical Methods: Used as a reference standard in chromatographic (HPLC) and mass spectrometric (MS) analyses for quality control and method validation.

Basic Information

Product Name	Fibronectin Fragment (1376-1380)
CAS No.	158622-13-0
Molecular Formula	C27H44N8O8
Molecular Weight	608.69 g/mol
Synonyms	Fibronectin Cell-Adhesion Peptide; Arg-Gly-Asp-Ser-Pro; RGDSP Peptide; GRGDSP; H-Arg-Gly-Asp-Ser-Pro-OH; Fibronectin (1376-1380); Adhesion Peptide RGDSP; Fibronectin Fragment 1376-1380
EINECS	Contact for details

Quality Control

Our Fibronectin Fragment (1376-1380) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable outcomes for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.