Description

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-Nh2 CAS NO 158584-09-9 is a synthetic, fluorogenic peptide substrate specifically engineered for biochemical research and diagnostic applications. This compound is a critical tool for the study and detection of specific protease activities, offering high sensitivity and selectivity in enzymatic assays. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic kit manufacturers focused on enzymology, drug discovery, and biomarker detection.

Application

• Protease Activity Assays: Used as a selective fluorogenic substrate for monitoring the kinetics and inhibition of specific proteolytic enzymes in vitro.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors as potential therapeutic agents.
• Biochemical Research: Serves as a key reagent in fundamental research to elucidate protease function, substrate specificity, and signaling pathways.
• Diagnostic Development: Integrated into the development of clinical diagnostic assays for detecting abnormal protease levels associated with various diseases.
• Quality Control in Biologics: Applied in the biopharmaceutical industry to test for residual protease activity during downstream purification processes.

Basic Information

Product Name	Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-Nh2
CAS No.	158584-09-9
Molecular Formula	C78H108N22O19S
Molecular Weight	1681.9 g/mol
Synonyms	7-Methoxycoumarin-4-acetyl-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(2,4-Dinitrophenyl)-NH2; Mca-RPKPYANW-MK(Dnp)-NH2; Fluorogenic Peptide Substrate 158584-09-9; Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Norval-Trp-Met-Lys(Dnp)-Amide; Protease Substrate IV; MMP Substrate; FRET Peptide Substrate
EINECS	Contact for details

Quality Control

Our Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis to meet specific purity or packaging requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to warm to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.