Description

Fmoc-Ala-Cys[Psi(Me,Me)Pro]-Oh CAS NO 158531-43-2 is a specialized, high-purity pseudoproline-containing dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for introducing conformational constraints into peptide chains, which can significantly improve synthesis efficiency and prevent aggregation. It is an essential raw material for researchers and manufacturers in pharmaceutical development, particularly for creating complex therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the Fmoc-strategy synthesis of complex and difficult-sequence peptides.
• Pharmaceutical R&D: Used in the discovery and development of novel therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Design: The pseudoproline moiety is instrumental in creating stable, bioactive peptide analogs with enhanced pharmacological properties.
• Conformational Studies: Employed to study peptide folding, secondary structure formation, and stability in solution.
• Bioconjugation: The cysteine thiol group provides a handle for site-specific modifications, labeling, or cyclization.
• High-Value API Intermediate: Serves as a critical intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) for clinical trials and commercial production.

Basic Information

Item	Detail
Product Name	Fmoc-Ala-Cys[Psi(Me,Me)Pro]-Oh
CAS No.	158531-43-2
Molecular Formula	C27H31N3O6S
Molecular Weight	525.62 g/mol
Synonyms	Fmoc-Ala-Cys(ψMe,Mepro)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanyl-S-[(2S,4R)-1-methyl-4-(1-methylethyl)-2-pyrrolidinyl]-L-cysteine; Fmoc-L-Ala-L-Cys[ψ(Me,Mepro)]-OH; Fmoc-Ala-Cys(ψMe,MePro)-OH; Pseudoproline Dipeptide Derivative; Fmoc-Protected Pseudoproline Building Block
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Ala-Cys[Psi(Me,Me)Pro]-Oh is manufactured under controlled conditions and undergoes stringent analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from HPLC, NMR, and mass spectrometry. Our quality management system supports compliance with cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and production workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.