Description

Fmoc-Homoarg(Boc)2-Oh is a protected amino acid derivative, specifically an Fmoc- and Boc-protected homoarginine building block, essential for solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled, sequential assembly of complex peptides by providing orthogonal protection for the guanidino group, preventing unwanted side reactions. This high-purity intermediate is critically needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated, stepwise synthesis of peptides containing homoarginine residues.
• Pharmaceutical R&D: Used in the research and development of peptide-based drugs targeting various diseases, where homoarginine can influence bioavailability and receptor binding.
• Bioconjugation & Probe Development: Serves as a modified amino acid for creating labeled peptides or affinity tags used in biochemical assays and diagnostic tools.
• Structure-Activity Relationship (SAR) Studies: Enables medicinal chemists to study the effect of arginine homologs on peptide potency, selectivity, and metabolic stability.
• Custom Peptide Service Providers: A fundamental reagent for CROs and manufacturers offering bespoke peptide synthesis services to the global research community.

Basic Information

Product Name	Fmoc-Homoarg(Boc)2-Oh
CAS No.	158478-81-0
Molecular Formula	C32H43N5O8
Molecular Weight	625.72 g/mol
Synonyms	Fmoc-Homoarginine(Boc)2-OH; Nα-Fmoc-NG,NG'-bis(tert-butoxycarbonyl)-L-homoarginine; Fmoc-L-homoarginine(Boc)2; Nα-(9-Fluorenylmethoxycarbonyl)-NG,NG'-bis(tert-butoxycarbonyl)homoarginine; (2S)-5-[[(Bis(tert-butoxycarbonyl)amino]](methyl)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; Fmoc-Har(Boc)2-OH; Fmoc-NG,NG'-Bis-Boc-homoarginine
EINECS	Contact for details

Quality Control

Our Fmoc-Homoarg(Boc)2-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for advanced peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.