Description

Z-L-Valine Nca CAS NO 158257-41-1 is a specialized N-carboxyanhydride (NCA) derivative of the amino acid L-valine, serving as a high-purity building block for controlled peptide synthesis. This compound is critical for researchers and manufacturers requiring precise, reproducible polymerization to create well-defined polypeptides and advanced biomaterials. It is essential for the pharmaceutical, biotechnology, and advanced materials sectors, where the integrity of the amino acid side chain and polymerization control are paramount.

Application

• Ring-Opening Polymerization (ROP): Primary monomer for the synthesis of poly(L-valine) and valine-based copolymers with controlled molecular weights and low polydispersity.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug delivery systems.
• Biomaterial Fabrication: Key component in creating biodegradable polymers, hydrogels, and scaffolds for tissue engineering and regenerative medicine.
• Advanced Material Science: Enables the production of polypeptides with specific secondary structures (e.g., β-sheets) for functional materials.
• Conjugate Synthesis: Facilitates the creation of peptide-polymer conjugates for diagnostic and therapeutic applications.
• Academic & Industrial R&D: A fundamental reagent for studying polymerization mechanisms and developing novel polypeptide architectures.

Basic Information

Product Name	Z-L-Valine Nca
CAS No.	158257-41-1
Molecular Formula	C14H15NO5
Molecular Weight	277.27 g/mol
Synonyms	Nε-Carbobenzoxy-L-valine N-carboxyanhydride; Z-L-Valine N-Carboxyanhydride; Z-Val-NCA; NCA of Z-L-Valine; (S)-4-((Benzyloxycarbonyl)amino)-2-methyl-5-oxo-4,5-dihydrooxazole; CBZ-L-Valine NCA; N-(Benzyloxycarbonyl)-L-valine N-carboxyanhydride; L-Valine, N-[(phenylmethoxy)carbonyl]-, anhydride with carbonic acid
EINECS	Contact for details

Quality Control

Our Z-L-Valine Nca is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive polymerization reactions. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, assay, and impurity profiles. Our quality system is designed to support GMP-grade applications and rigorous research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent premature hydrolysis and loss of reactivity. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in THF, DMF, DMSO; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.