Description

Fmoc-Ser(Po3H2)-Oh is a protected, phosphorylated serine derivative used in solid-phase peptide synthesis (SPPS). This compound is critical for the site-specific incorporation of phosphoserine, enabling the study of protein phosphorylation—a fundamental regulatory mechanism in biology. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and biochemical research, particularly for creating phosphopeptides and mimetics for drug discovery and diagnostic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of phosphopeptides.
• Phosphoproteomics Research: For synthesizing standards, probes, and affinity reagents to study protein phosphorylation events.
• Drug Discovery & Development: Used to create phosphopeptide-based inhibitors, antigens, and therapeutic candidates targeting kinases and phosphatases.
• Bioconjugation & Material Science: Serves as a modified amino acid for creating functionalized surfaces or biomaterials with phosphate handles.
• Antibody Production: Synthesis of phospho-specific peptide antigens for generating phosphorylation-state-specific antibodies.
• Enzyme Substrate & Inhibitor Studies: Preparation of defined substrates for kinase/phosphatase activity assays and inhibitor screening.

Basic Information

Product Name	Fmoc-Ser(Po3H2)-Oh
CAS No.	158171-15-4
Molecular Formula	C₁₈H₂₀NO₈P
Molecular Weight	409.33 g/mol
Synonyms	Fmoc-O-phospho-L-serine; Fmoc-Ser(PO3H2)-OH; Fmoc-L-phosphoserine; N-(9-Fluorenylmethoxycarbonyl)-O-phosphono-L-serine; Fmoc-PSer-OH; Nα-Fmoc-O-phosphono-L-serine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-phosphonooxypropanoic acid; Fmoc-Ser(PO(OH)2)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Po3H2)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This material is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry atmosphere before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.