Description

Fmoc-o-(Benzylphospho)-L-Serine is a specialized, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a crucial building block for the site-specific incorporation of phosphoserine, enabling the study of protein phosphorylation and signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in the development of peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key phosphoamino acid building block for the Fmoc-strategy synthesis of phosphopeptides.
• Phosphopeptide Synthesis: Enables the controlled introduction of phosphoserine residues to mimic post-translational modifications for biological studies.
• Biochemical Research: Used in the preparation of substrates for kinase/phosphatase activity assays and enzyme specificity studies.
• Pharmaceutical Development: Critical for creating peptide drug candidates that target phosphorylation-dependent protein-protein interactions.
• Antibody Production: Employed to synthesize phosphopeptide antigens for generating phosphorylation site-specific antibodies.
• Proteomics & Signal Transduction Research: Facilitates the study of cellular signaling networks by providing access to defined phosphopeptides.

Basic Information

Product Name	Fmoc-o-(Benzylphospho)-L-Serine
CAS No.	158171-14-3
Molecular Formula	C25H24NO7P
Molecular Weight	481.43 g/mol
Synonyms	Fmoc-Ser(PO(OBzl)OH)-OH; N-(9-Fluorenylmethoxycarbonyl)-O-(benzylphospho)-L-serine; Fmoc-O-(benzylphosphono)-L-serine; Fmoc-L-Ser(PO(OBzl)OH)-OH; Fmoc-Ser(PO3Bzl)-OH; Fmoc-Phospho-L-serine(benzyl); Fmoc-O-phosphono-L-serine benzyl ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-[benzyloxy(phosphono)oxy]propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-o-(Benzylphospho)-L-Serine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing compliance with the highest standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.