Description

Retro-Arg-Malonyl-Asp-Oh is a specialized, non-natural amino acid derivative featuring a retro-inverso peptide bond configuration. This compound is of significant value in advanced pharmaceutical research and development, particularly for creating metabolically stable peptide mimetics and enzyme inhibitors. It is primarily utilized by researchers and manufacturers in the life sciences sector for drug discovery, proteomics, and the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Research & Development: As a key building block for the synthesis of retro-inverso peptides with enhanced stability against proteolytic degradation.
• Protease Inhibitor Design: Used in the development of potent and selective inhibitors for aspartic proteases and other enzyme targets.
• Medicinal Chemistry: Serves as a crucial intermediate for constructing peptide-based drug candidates with improved pharmacokinetic properties.
• Bioconjugation & Probe Synthesis: Employed in the creation of labeled peptides and molecular probes for biochemical and diagnostic applications.
• Academic & Institutional Research: Utilized in university and institutional labs for studying peptide structure-activity relationships and novel therapeutic modalities.

Basic Information

Product Name	Retro-Arg-Malonyl-Asp-Oh
CAS No.	158156-78-6
Molecular Formula	C₁₃H₂₂N₆O₇
Molecular Weight	374.35 g/mol
Synonyms	N-[(2S)-5-(Diaminomethylideneamino)-1-[[(2S)-1-hydroxy-3-(C-hydroxycarbonimidoyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]-L-asparagine; Retro-L-Arg-L-Mal-L-Asp-OH; (2S)-2-[[(2S)-5-(Diaminomethylideneamino)-1-[[(2S)-1-hydroxy-3-(C-hydroxycarbonimidoyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-3-carbamoylpropanoic acid; Malonyl Retro Peptide Building Block; Arg-Mal-Asp Retro-Inverso Isomer
EINECS	Contact for details

Quality Control

Our Retro-Arg-Malonyl-Asp-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.