Description

Factor Xiiia Fragment 72-97 CAS NO 158053-05-5 is a defined synthetic peptide sequence corresponding to a specific region of the human blood coagulation Factor XIII A subunit. This fragment is a critical research tool for studying the structure, function, and activation mechanisms of Factor XIIIa, an enzyme essential for fibrin clot stabilization. It is primarily utilized by researchers and developers in the fields of hemostasis, thrombosis, and cardiovascular disease, as well as by diagnostic and pharmaceutical companies for assay development and drug discovery.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study Factor XIIIa activity and kinetics.
• Diagnostic Development: Serves as a key component in the development of immunoassays (ELISA) and activity tests for measuring Factor XIII levels in clinical samples.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel modulators (activators or inhibitors) of Factor XIIIa for therapeutic purposes.
• Structural Biology: Provides a defined peptide target for X-ray crystallography, NMR spectroscopy, and molecular modeling studies to elucidate interaction sites.
• Antibody Production: Acts as an immunogen for generating specific polyclonal or monoclonal antibodies against the Factor XIII A subunit.
• Quality Control: Used as a reference standard in the quality control of diagnostic kits and biopharmaceutical products related to coagulation.

Basic Information

Product Name	Factor Xiiia Fragment 72-97
CAS No.	158053-05-5
Molecular Formula	C138H215N43O39
Molecular Weight	3088.4 g/mol
Synonyms	Factor XIII A Chain Fragment 72-97; Coagulation Factor XIII A Chain (72-97); F13A1 (72-97); Fibrin-Stabilizing Factor A Subunit Fragment; Recombinant Factor XIIIa Peptide; H-Gln-Val-Ser-Gln-Leu-Trp-Ser-Pro-Asp-Arg-Ala-Gln-Ile-Met-Gly-His-Glu-Val-Gly-Gly-Arg-Gly-Arg-Arg-NH2; FXIIIa (72-97); A13 peptide.
EINECS	Contact for details

Quality Control

Our Factor Xiiia Fragment 72-97 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Amino Acid Sequence	H-QVSQLWSPDRAQIMGHEVGGGRGRR-NH2
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.