Description

(N4-Bz)-5-Iodo-2'-Deoxycytidine is a key nucleoside derivative, specifically a modified 2'-deoxycytidine analog, widely used as a critical building block in oligonucleotide synthesis and pharmaceutical research. Its primary value lies in its role as a versatile intermediate for the development of novel therapeutic agents, including antisense oligonucleotides and prodrugs, where precise chemical modification is essential. This high-purity compound is indispensable for research and development teams in the pharmaceutical, biotechnology, and diagnostic sectors focused on nucleic acid chemistry and targeted drug discovery.

Application

• Oligonucleotide Synthesis: A crucial phosphoramidite precursor for the solid-phase synthesis of modified DNA strands, enabling the site-specific incorporation of iodine for further functionalization or labeling.
• Antisense & siRNA Drug Development: Serves as a key intermediate in the research and production of antisense oligonucleotides and small interfering RNA (siRNA) therapeutics designed for targeted gene silencing.
• Prodrug Synthesis: Used in the chemical synthesis of nucleoside prodrugs, where the benzoyl (Bz) and iodo modifications can be leveraged for controlled release or enhanced targeting.
• Bioconjugation & Labeling: The iodine atom provides a handle for further chemical reactions, such as radioiodination for tracer studies or coupling to other molecules via cross-linking chemistry.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies in the search for new antiviral and anticancer agents based on nucleoside analogs.
• Diagnostic Probe Development: Employed in the creation of labeled DNA probes for diagnostic assays and genomic research applications.

Basic Information

Product Name	(N4-Bz)-5-Iodo-2'-Deoxycytidine
CAS No.	158042-39-8
Molecular Formula	C16H16IN3O5
Molecular Weight	457.22 g/mol
Synonyms	5-Iodo-N4-benzoyl-2'-deoxycytidine; N4-Benzoyl-5-iodo-2'-deoxycytidine; 5-Iodo-2'-deoxycytidine N4-benzoate; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodo-4-(benzoylamino)pyrimidin-2(1H)-one; 5-I-dC(Bz)
EINECS	Contact for details

Quality Control

Our (N4-Bz)-5-Iodo-2'-Deoxycytidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the rigorous standards demanded by the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.