Description

Fa-Lys-Leu-Oh is a protected tripeptide derivative featuring formyl (Fa) and benzyloxycarbonyl (Z) protecting groups on the N-terminus and lysine side chain, respectively. This specific protection pattern makes it a valuable and versatile building block for the solid-phase and solution-phase synthesis of more complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel therapeutic peptides.
• Peptide Synthesis Building Block: Used in both Fmoc and Boc solid-phase peptide synthesis (SPPS) strategies to introduce the Lys-Leu sequence with orthogonal protection.
• Bioconjugation & Probe Development: Serves as a starting material for creating labeled peptides or peptide-based probes for biochemical assays.
• Structure-Activity Relationship (SAR) Studies: Enables the systematic modification of peptide sequences to study their biological activity and optimize drug candidates.
• Academic & Industrial Research: Employed in laboratories for investigating peptide chemistry, enzyme substrates, and hormone analogs.

Basic Information

Product Name	Fa-Lys-Leu-Oh
CAS No.	158016-09-2
Molecular Formula	C₂₃H₃₆N₄O₆
Molecular Weight	464.56 g/mol
Synonyms	N-Formyl-Nε-Z-L-lysyl-L-leucine; Nα-Formyl-Nε-carbobenzoxy-L-lysyl-L-leucine; For-Lys(Z)-Leu-OH; N-For-Nε-Cbz-L-Lys-L-Leu-OH; FA-LYS(COZ)-LEU-OH; (2S)-2-[[(2S)-6-[(Benzyloxy)carbonyl]amino-2-formamidohexanoyl]amino]-4-methylpentanoic acid; N-Formyl-Nε-benzyloxycarbonyl-L-lysyl-L-leucine
EINECS	Contact for details

Quality Control

Our Fa-Lys-Leu-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Optical Rotation	-20° to -25° (c=1, DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.