Description

2,3,4-Trifluorobenzyl Bromide is a versatile and high-value fluorinated aromatic building block essential for advanced organic synthesis. Its primary value lies in introducing the trifluoromethylbenzyl moiety, which is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is particularly vital for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in developing central nervous system (CNS) drugs, kinase inhibitors, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs).
• Organic Electronics: Employed in the synthesis of novel organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Cross-Coupling Reactions: Acts as an effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry teams exploring new chemical entities and optimizing synthetic routes.

Basic Information

Item	Details
Product Name	2,3,4-Trifluorobenzyl Bromide
CAS No.	157911-55-2
Molecular Formula	C7H4BrF3
Molecular Weight	225.01 g/mol
Synonyms	α-Bromo-2,3,4-trifluorotoluene; (2,3,4-Trifluorophenyl)methyl Bromide; 2,3,4-Trifluoro-α-bromotoluene; 2,3,4-Trifluorobenzylbromide; 1-(Bromomethyl)-2,3,4-trifluorobenzene; Bromo(2,3,4-trifluorophenyl)methane
EINECS	Contact for details

Quality Control

Our 2,3,4-Trifluorobenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.