Description

Amyloid β-Protein (3-42) is a specific proteolytic fragment of the amyloid precursor protein (APP), a key peptide of interest in Alzheimer's disease and related neurological research. This peptide is crucial for studying the mechanisms of amyloid beta aggregation, plaque formation, and neurotoxicity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic developers focused on neurodegenerative diseases and therapeutic target validation.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, structure, and toxicity of amyloid beta peptides.
• Drug Discovery & Screening: Used as a target or reagent in high-throughput assays to identify and evaluate potential inhibitors of amyloid aggregation.
• Antibody & Diagnostic Development: Serves as an antigen for the production and characterization of specific antibodies used in ELISA, Western blot, and immunohistochemistry assays.
• Neurodegenerative Disease Modeling: Employed in in vitro and cellular models to simulate pathological processes associated with Alzheimer's disease.
• Biophysical Studies: Analysis of peptide secondary structure, oligomerization, and membrane interactions using techniques like circular dichroism (CD) and surface plasmon resonance (SPR).
• Reference Standard: Acts as a purified standard for quantitative analysis in mass spectrometry and chromatographic methods.

Basic Information

Product Name	Amyloid β-Protein (3-42)
CAS No.	157884-74-7
Molecular Formula	C185H277N51O57S
Molecular Weight	4085.6 g/mol
Synonyms	Amyloid Beta Protein (3-42); Aβ (3-42); Amyloid β-Peptide (3-42); β-Amyloid Peptide (3-42); Aβ1-42 (3-42 fragment); APP (672-713); Amyloid Precursor Protein Fragment (3-42)
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (3-42) is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is characterized by multiple analytical techniques to confirm identity, purity, and peptide content. Certificates of Analysis (COA) detailing purity (by HPLC), molecular weight verification (by Mass Spectrometry), and endotoxin levels are provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in water or dilute acetic acid
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.