Description

Enkephalinamide-Leu, Cyclo(Alpha,γ-Dibutyric Acid(2)-Glutamyl(3))- CAS NO 157878-99-4 is a synthetic, cyclic peptide derivative structurally related to enkephalins, which are endogenous opioid peptides. This compound is of significant interest for its potential role in neurological and pharmacological research, particularly in the study of opioid receptor interactions and signal transduction pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in peptide chemistry and neurobiology.

Application

• Pharmacological Research: As a reference standard or active compound in studies investigating opioid receptor (e.g., μ, δ) binding affinity, selectivity, and functional activity.
• Neuroscience Studies: For exploring the physiological and pathophysiological roles of enkephalinergic systems in pain modulation, mood, and addiction.
• Peptide Drug Discovery: Serving as a key intermediate or lead compound in the design and synthesis of novel peptide-based therapeutics with enhanced stability and bioavailability.
• Biochemical Assay Development: Used in the development and validation of high-throughput screening (HTS) assays and analytical methods (e.g., ELISA, HPLC-MS) for opioid peptides.
• Structure-Activity Relationship (SAR) Analysis: A critical tool for medicinal chemists to understand how structural modifications of the enkephalin core affect biological potency and metabolic stability.
• Academic Teaching & Reference: Employed in advanced university courses and laboratories specializing in peptide synthesis, neuropharmacology, and medicinal chemistry.

Basic Information

Item	Details
Product Name	Enkephalinamide-Leu, Cyclo(Alpha,γ-Dibutyric Acid(2)-Glutamyl(3))-
CAS No.	157878-99-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cyclo(α,γ-dibutyric acid(2)-Glu(3))-Leu-Enkephalinamide; Cyclo(2,3)-Dibutyryl-Glu-Leu-Enkephalinamide; Cyclic Leu-Enkephalinamide derivative; Cyclo(Dibutyryl-Glu)-Leu-Enkephalin; Opioid peptide cyclic analog; Cyclo(2,3)-α,γ-Dibutyryl-Glutamyl-Leu-Enkephalinamide; H-Tyr-Gly-Gly-Phe-Leu-NH₂ cyclic analog (2,3-dibutyryl-Glu); Research peptide 157878-99-4
EINECS	Contact for details

Quality Control

Our Enkephalinamide-Leu, Cyclo(Alpha,γ-Dibutyric Acid(2)-Glutamyl(3))- is produced under controlled conditions to ensure high purity and batch-to-batch consistency, critical for reliable research outcomes. All products undergo rigorous quality testing, including HPLC for purity assessment and mass spectrometry for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other relevant specifications is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For extended storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.