Description

2,3,5,6-Tetrafluorotyrosine is a fluorinated derivative of the essential amino acid tyrosine, distinguished by the strategic substitution of hydrogen atoms with fluorine at the 2, 3, 5, and 6 positions of the aromatic ring. This specific fluorination pattern makes it a critical building block in advanced pharmaceutical research, particularly for the development of novel PET (Positron Emission Tomography) imaging agents and targeted therapeutics. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in radiochemistry, medicinal chemistry, and the synthesis of bioactive peptides.

Application

• Radiopharmaceutical Precursor: A key intermediate in the synthesis of fluorine-18 (18F) labeled compounds for PET imaging, used in oncology and neurology research.
• Medicinal Chemistry: Serves as a non-natural amino acid analog for structure-activity relationship (SAR) studies and the development of enzyme inhibitors or receptor ligands.
• Peptide Synthesis: Incorporated into custom peptides to enhance metabolic stability, modulate lipophilicity, or serve as a spectroscopic probe.
• Biochemical Research: Used as a tool compound to study tyrosine kinase activity, phosphorylation processes, and signal transduction pathways.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2,3,5,6-Tetrafluorotyrosine
CAS No.	157807-83-5
Molecular Formula	C9H7F4NO3
Molecular Weight	253.15 g/mol
Synonyms	2,3,5,6-Tetrafluoro-L-tyrosine; L-2,3,5,6-Tetrafluorotyrosine; (2S)-2-Amino-3-(2,3,5,6-tetrafluoro-4-hydroxyphenyl)propanoic acid; 2,3,5,6-Tetrafluoro-4-hydroxy-L-phenylalanine; Tetrafluorotyrosine; TFT; F4-Tyr
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetrafluorotyrosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.