Description

Ac-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2 CAS NO 157382-69-9 is a synthetic, phosphorylated heptapeptide sequence of significant interest in biochemical and pharmaceutical research. This compound serves as a critical tool for studying signal transduction pathways, particularly those involving tyrosine phosphorylation and protein-protein interactions. It is primarily utilized by research institutions and biotechnology companies focused on kinase/phosphatase activity assays, antibody development, and metabolic pathway analysis. The peptide's defined structure and post-translational modification make it an essential standard and reagent in proteomics and drug discovery.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in enzymatic studies of tyrosine kinases and phosphatases.
• Antibody Production & Validation: Serves as a key antigen for generating and screening phospho-specific antibodies.
• Cell Signaling Studies: Employed in cellular assays to modulate or trace intracellular signaling cascades.
• Diagnostic Development: Acts as a critical component in the development of ELISA and other immunoassay kits for detecting phosphorylation events.
• Drug Discovery & Screening: Utilized in high-throughput screening (HTS) platforms to identify novel kinase inhibitors or activators.
• Proteomics & Mass Spectrometry: Functions as a reference standard for the identification and quantification of phosphorylated peptides in complex samples.

Basic Information

Product Name	Ac-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
CAS No.	157382-69-9
Molecular Formula	C38H60N9O16PS
Molecular Weight	961.98 g/mol
Synonyms	Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-amide; N-Acetyl-L-aspartyl-O-phosphono-L-tyrosyl-L-valyl-L-prolyl-L-methionyl-L-leucinamide; Phosphorylated Heptapeptide (Ac-DY(P)V-PML-NH2); pTyr Peptide Substrate; pY Peptide; Kinase Substrate Peptide; Phosphopeptide Standard; Research Peptide 157382-69-9
EINECS	Contact for details

Quality Control

Every batch of Ac-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2 is manufactured and analyzed under strict quality management systems. We guarantee high purity levels suitable for demanding research applications, with comprehensive testing including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.