Description

Antalarmin Hydrochloride is a potent and selective non-peptide antagonist of the corticotropin-releasing factor (CRF) receptor subtype 1 (CRF1). This compound is of significant value in neuroscience and pharmaceutical research for its ability to modulate the stress response system. It is primarily utilized by researchers and developers in the life sciences sector for investigating stress-related disorders, anxiety, depression, and substance abuse.

Application

• Neuroscience Research: A critical tool for studying the role of the CRF system in stress, anxiety, and depression models.
• Pharmacological Studies: Used in vitro and in vivo to characterize CRF1 receptor function and screen for novel therapeutics.
• Psychiatric Disorder Research: Investigation of potential therapeutic pathways for anxiety disorders and major depressive disorder.
• Substance Abuse Research: Exploration of stress-induced relapse mechanisms for drugs of abuse, including alcohol and cocaine.
• Preclinical Development: Serves as a reference compound in the development of new CRF1 receptor antagonists.
• Academic & Institutional Labs: Fundamental research in neuroendocrinology and behavioral pharmacology.

Basic Information

Product Name	Antalarmin Hydrochloride
CAS No.	157284-96-3
Molecular Formula	C32H41N3O2 • HCl
Molecular Weight	552.15 g/mol
Synonyms	N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride; Antalarmin HCl; CRF1 Receptor Antagonist; NBI 27914; NBI-27914; Pyrrolopyrimidine CRF antagonist; 7H-Pyrrolo[2,3-d]pyrimidine, N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our Antalarmin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and residual solvent analysis to ensure it meets high-purity research standards. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.