Description

Protegrin Pg-4 is a synthetic antimicrobial peptide (AMP) analog, designed to mimic the potent, broad-spectrum activity of natural protegrins. This compound is valued for its ability to disrupt microbial cell membranes, offering a powerful mechanism of action against bacteria, fungi, and some enveloped viruses. It is primarily utilized in advanced biomedical research, pharmaceutical development, and the formulation of novel antimicrobial agents targeting drug-resistant pathogens.

Application

• Antimicrobial Agent Research: Serves as a key reference standard and active component in studies exploring novel mechanisms to combat antibiotic-resistant bacteria (e.g., MRSA, VRE).
• Pharmaceutical Development: Investigated for incorporation into topical formulations for wound care, dermatological infections, and medical device coatings.
• Biomaterial & Medical Device Coatings: Used in R&D to create infection-resistant surfaces for implants, catheters, and surgical tools.
• Veterinary Medicine: Explored for therapeutic applications in animal health to treat bacterial and fungal infections.
• Cosmeceutical Preservative Systems: Evaluated as a potential natural-origin preservative booster in high-value skincare formulations.
• Basic Biochemical & Biophysical Studies: Employed to study peptide-lipid interactions, membrane permeabilization, and structure-activity relationships (SAR) of antimicrobial peptides.

Basic Information

Product Name	Protegrin Pg-4
CAS No.	157214-61-4
Molecular Formula	C90H148N30O19
Molecular Weight	~1882.3 g/mol
Synonyms	PG-4; Protegrin-4; RGGGLCYRCRFCVCVGR-NH2 (disulfide bridges: Cys7-Cys13, Cys8-Cys15); IB-367 (related investigational drug name); Antimicrobial Peptide Pg-4; Synthetic Protegrin Analog; (Arg-Gly-Gly-Gly-Leu-Cys-Tyr-Arg-Cys-Arg-Phe-Cys-Val-Cys-Val-Gly-Arg) amide
EINECS	Contact for details

Quality Control

Our Protegrin Pg-4 is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including reversed-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and related substance profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.