Description

Pod-Ii CAS NO 156928-68-6 is a high-purity chemical intermediate, also known as 2'-Deoxy-2'-fluoro-2'-C-methyluridine, primarily utilized in advanced pharmaceutical synthesis. This compound is critical for the research and development of novel antiviral therapeutics, particularly in the nucleoside analog class. It serves as a key building block for medicinal chemists and pharmaceutical manufacturers targeting RNA virus infections, where precise molecular structure is paramount for biological activity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of investigational nucleoside analog drugs for antiviral applications.
• Antiviral Drug Research: Used in R&D for potential therapeutics targeting hepatitis C virus (HCV) and other RNA viruses.
• Medicinal Chemistry: Serves as a specialized scaffold for structure-activity relationship (SAR) studies and prodrug development.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate viral polymerase mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Pod-Ii
CAS No.	156928-68-6
Molecular Formula	C10H13FN2O5
Molecular Weight	260.22 g/mol
Synonyms	2'-Deoxy-2'-fluoro-2'-C-methyluridine; 2'-Fluoro-2'-C-methyluridine; PSI-6130; PSI 6130; RO-2433; 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; β-2'-Deoxy-2'-fluoro-2'-C-methyluridine; NSC 781164
EINECS	Contact for details

Quality Control

Our Pod-Ii is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development needs with material produced under GMP-like conditions for non-clinical and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.