Description

Amyloid β-Protein (17-40) Ammonium Salt is a synthetic peptide fragment corresponding to a specific region of the amyloid-beta protein, a key molecule in neurological research. This high-purity biochemical is essential for studying protein aggregation mechanisms and developing diagnostic tools for neurodegenerative conditions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers focused on Alzheimer's disease and related pathologies.

Application

• Biomedical Research: Fundamental studies on amyloid-beta aggregation kinetics, oligomer formation, and neurotoxicity.
• Therapeutic Development: Screening and validation of potential drug candidates designed to inhibit amyloid plaque formation.
• Diagnostic Assays: Used as a critical antigen or standard in ELISA, Western Blot, and other immunoassays for detecting amyloid-β-related biomarkers.
• Antibody Production: Acts as an immunogen for generating specific monoclonal or polyclonal antibodies against the amyloid-beta protein.
• Biophysical Studies: Employed in structural analysis using techniques like NMR, CD spectroscopy, and electron microscopy.
• Cell Culture Models: Application in neuronal cell culture systems to model amyloid-induced cytotoxicity and study cellular pathways.

Basic Information

Product Name	Amyloid β-Protein (17-40) Ammonium Salt
CAS No.	156790-69-1
Molecular Formula	C106H173N33O34 • xNH3
Molecular Weight	~2380.7 g/mol (free acid, theoretical)
Synonyms	Aβ(17-40); Amyloid β-Protein (17-40); β-Amyloid (17-40); Amyloid Beta Peptide (17-40); Aβ17-40; Amyloid β-Peptide Fragment 17-40; Amyloid β-Protein Fragment 17-40 Ammonium Salt
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (17-40) Ammonium Salt is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry for identity confirmation. We provide Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to store under an inert atmosphere or desiccated conditions. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or dilute aqueous acetic acid
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.